Proton therapy for cervical cancer

Proton therapy for cervical cancer

Project aim

Mainly due to differences in bladder and rectal filling, large inter- and intrafraction motion can occur in radiotherapy of cervical cancer. We study proton therapy treatment planning techniques using various bladder fillings and robust optimization features. To determine the most efficient treatment, the resulting treatment plans will be compared to the conventional approach (photon VMAT planning technique) and to other adaptive treatment strategies .

CT-scan and dose distribution (sagittal view) for a cervical cancer patient, during the course of treatment. CT-scan and dose distribution (sagittal view) for a cervical cancer patient, during the course of treatment.

The left hand pane of the image above shows the dose distribution from a proton plan that was not robust to variations in bladder filling. The right hand pane shows the dose distribution from a optimized robust proton plan, correctly covering the target volume (CTV) for the new patient anatomy.

People involved

Witold Matysiak, Charlotte Brouwer, Jannet Beukema, Stefan Bijmolt.

Collaborators

Amsterdam Medical Center (AMC), Amsterdam

References

A. van de Schoot. Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer 2016 Acta Oncologica (pdf)